*corresponding authors
Journal Articles
2025
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Synthesis of Mixed Phosphine–Phosphine Oxide Ligands by Rh(I)-Catalyzed C─H Bond Alkylation
L. Geminiani, R. Jackstell, K. Junge, M. Beller,* J.-F. Soulé*. ChemCatChem 2025, 17, e00639. (10.1002/cctc.202500639). Link -
Ir/Ni Metallaphotoredox Catalysis for the C(sp3)─H Bond α-Arylation and Alkylation of N-Alkyl N-Heterocycles
B. Lv, F. Ling, J.-F. Soulé*. Chem. Eur. J. 2025, 31, e202500938. (10.1002/chem.202500938). Link -
Mechanochemical Approach for Metal-Free Regioselective C5-Sulfenylation of Imidazo[2,1-b]Thiazoles
X. Liu, V. Dorokhov, O. Provot, C. Tran, P. Retailleau, J.-F. Soulé,* A. Hamze*. ChemSusChem 2025,18, e202500320. (10.1002/cssc.202500320). Link -
Room-Temperature Rh(I)-Catalyzed P(III)-Directed C–H Bond Alkylation: Enhanced Reactivity through Ligand Acceleration
J. Zhang, J.-F. Soulé*. ACS Catal. 2025, 2839-2846. (10.1021/acscatal.4c05673). Link -
PIFA-Mediated Cyclization of Methyl(2-(1-Phenylvinyl)Phenyl)Sulfane for the Concise, Flexible, and Scalable De Novo Synthesis of C3-Arylated Benzo[b]Thiophenes
X. Liu, O. Provot,* C. Tran,* J. F. Soulé, A. Hamze*. Org. Chem. Front. 2025, 12, 24-32. (10.1039/D4QO01589D). Link
2024
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Nickel/Iridium Metallaphotoredox Catalysis for Allylic C–H Bond Arylation of N-Allyl Heterocycles
B. Lv, J.-F. Soulé*. J. Org. Chem. 2024, 89, 16028-16032. (10.1021/acs.joc.4c01912). Link -
Rhodium-Catalyzed C–H Bond Annulation for the Synthesis of 5- and 6-Membered N-Heterocyclic Building Blocks
M. Peng, H. Doucet, J.-F. Soulé*. ChemCatChem 2024, e202400279. (10.1002/cctc.202400279). Link -
From Molecules to Devices: Effect of Pd-Catalyzed C–H Bond Arylation to Improve Metrics
A. A. Wayzani, K. Zhang, A. Benzai, M. Cordier, H. Doucet, V. Guerchais, L. He,* J.-F. Soulé*. Organometallics 2024, 43, 889-894. (10.1021/acs.organomet.4c00018). Link
2023
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Rhodium(I)-Catalyzed Cascade Csp2–H Bond Alkylation – Amidation of Anilines: Phosphorus as Traceless Directing Group
M. Peng, D. Ari, T. Roisnel, H. Doucet, J.-F. Soulé*. Chem. Sci. 2023, 14, 9055-9062. (10.1039/d3sc02992a). Link -
Merging C–H Bond Activation, Alkyne Insertion, and Rearrangements by Rh(III)-Catalysis: Oxindole Synthesis from Nitroarenes and Alkynes
M. Peng, C.-S. Wang, P.-P. Chen, T. Roisnel, H. Doucet, K. N. Houk,* J.-F. Soulé*. J. Am. Chem. Soc. 2023, 145, 4508-4516. (10.1021/jacs.2c10932). Link
2022
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How Rhodium(I)-Catalyzed Phosphorus(III)-Directed C–H Bond Functionalizations Can Improve the Catalytic Activities of Phosphines
Z. Zuan, N. Durand, J.-F. Soulé*. Synlett 2022, 33, 705-712. (10.1055/s-0041-1737325). Link -
Upgrading Carbazolyl-Derived Phosphine Ligands Using RhI-Catalyzed PIII-Directed C–H Bond Alkylation for Catalytic CO2-Fixation Reactions
J. Rzayev, Z. Zhang, N. Durand, J.-F. Soulé*. Org. Lett. 2022, 24, 6755-6760. (10.1021/acs.orglett.2c02514). Link -
Photoinduced Arylation of Acridinium Salts: Tunable Photoredox Catalysts for C–O Bond Cleavage
Y-X. Cao, G. Zhu, Y. Li, N. Le Breton, C. Gourlaouen, S. Choua, J. Boixel,* H.-P. Jacquot de Rouville,* J.-F. Soulé*. J. Am. Chem. Soc. 2022, 144, 5902–5909. (10.1021/jacs.1021c12961). Link
2021
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Broadening of Horizons in the Synthesis of CD3-Labeled Molecules” Review Selected as Inside Cover
Q. Sun, J.-F. Soulé*. Chem. Soc. Rev. 2021, 50, 10806-10835. (10.1039/D1CS00544H). Link -
Synthesis of 2,2’-Bipyridines through Catalytic C−C Bond Formations from C−H Bonds
W. Hagui, K. Periasamy, J.-F. Soulé*. Eur. J. Org. Chem. 2021, 5388-5402. (10.1002/ejoc.202100806) Review Selected as VIP and Front Cover. Link -
Palladium-Catalyzed C–H Bond Arylation of Cyclometalated Difluorinated 2-Arylisoquinolinyl Iridium(III) Complexes
M. Peng, J. Lin, W. Lu,* T. Roisnel, V. Guerchais,* H. Doucet,* J.-F. Soulé*. Chem. Eur. J. 2021, 27, 12552-12557.(10.1002/chem.202102006). Link -
Access to Functionalized Luminescent Pt(II) Complexes by Photoredox-Catalyzed Minisci Alkylation of 6-Aryl-2,2’-bipyridines
W. Hagui, M. Cordier, J. Boixel,* J.-F. Soulé*. Chem. Commun. 2021, 57, 1038-1041. (10.1039/D0CC07307E). Link -
Palladium – Ruthenium Catalyst Complementarity Strengthens Ortho-Directed C–H bond Arylation of 2-Arylpyrazines
R.A. Benzai, F. Derridj, H. Doucet,* J.-F. Soulé*. ChemCatChem, 2021, 13, 338-345. (10.1002/cctc.202001338). Link -
Palladium-Catalyzed Direct Diarylation of 2-Benzyl-1,2,3-triazole: a Simple Access to 4-Aryl- or 4,5-Diaryl-2-benzyl-1,2,3-triazoles and Phenanthro[9,10-d][1,2,3]triazoles
Shi, J. Zhang, T. Roisnel, J.-F. Soulé,* H. Doucet*. Eur. J. Org. Chem. 2021, 2375-2382. (10.1002/ejoc.202100324). Link -
C−H Bond Arylation of Pyrazoles at the β-Position: General Conditions and Computational Elucidation for a High Regioselectivity
X. Shi, E. D. Sosa Carrizo, M. Cordier, J. Roger, N. Pirio, J.-C. Hierso, P. Fleurat-Lessard,* J.-F. Soulé,* H. Doucet*. Chem. Eur. J. 2021, 27, 5546-5554 (10.1002/chem.202100031). Link
2020
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Exploiting the Reactivity of Fluorinated 2-Arylpyridines in Pd-Catalyzed C–H Bond Arylation for the Preparation of Bright Emitting Iridium(III) Complexes
R. Boyaala, M. Peng, W.-S. Tai, R. Touzani, T. Roisnel, V. Dorcet, Y. Chi,* V. Guerchais,* H. Doucet,* J.-F. Soulé* . Inorg. Chem. 2020, 59, 13898-13911. (10.1021/acs.inorgchem.0c01528). Link -
Pd-Catalyzed Direct Arylations of Heteroarenes with Polyfluoroalkoxy-Substituted Bromobenzenes
H.-Y. Huang, H. Li, M. Cordier, J.-F. Soulé,* H. Doucet*. Eur. J. Org. Chem., 2020, Early View. (10.1002/ejoc.202001028). Link -
Regiodivergent Late-Stage Pd- or Ru-Catalyzed C–H Bond Functionalization Applied to the Straightforward Synthesis of N-Methylated Diflufenican Derivatives
M. E. Benhalouche, H. Li, A. Miloudi, A. Benzai, M. Cordier, J.-F. Soulé,* H. Doucet* . Eur. J. Org. Chem. 2020, 4792-4795. (10.1002/ejoc.202000749). Link -
Late-Stage Diversification of Biarylphosphines through Rhodium(I)-Catalyzed C–H Bond Alkenylation with Internal Alkynes
Z. Zhang, M. Cordier, P. H. Dixneuf, J.-F. Soulé* . Org. Lett. 2020, 22, 5936-5940. (10.1021/acs.orglett.0c02023). Link -
Synthesis of 2-Arylpyridines and 2-Arylbipyridines via Photoredox-Induced Meerwein Arylation with in Situ Diazotization of Anilines
W. Hagui, J.-F. Soulé* . J. Org. Chem. 2020, 85, 3655-3663. (10.1021/acs.joc.9b03306). Link -
Reactivity of Antipyrine and Haloantipyrines in Pd-Catalyzed C–H Bond Arylations
A. Sasmal, J. K. Bera, H. Doucet,* J.-F. Soulé* . Tetrahedron Lett. 2020, 61, 151798. (10.1016/j.tetlet.2020.151798). Link -
Direct Arylations of Heteroarenes with Benzenesulfonyl Chlorides Using Pd/C Catalyst
S. Mao, X. Shi, J.-F. Soulé,* H. Doucet* . Eur. J. Org. Chem. 2020, 91-97. (10.1002/ejoc.201901561). Link -
Regiocontrolled Palladium-Catalyzed direct C2-Arylations of Methoxalen using Benzenesulfonyl Chlorides and C2,C3-diDarylations using Aryl Bromides as the Aryl Sources
H. Li, T. Roisnel, J.-F. Soulé,* H. Doucet* . Tetrahedron Lett. 2020, 151342. (10.1016/j.tetlet.2019.151342). Link
2019
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Reactivity of N-Methyl-N-(polyfluorobenzyl)acetamides and N-Methyl-N-(polyfluorobenzyl)benzamides in Pd-Catalyzed C–H Bond Arylation
M. Elhadi Benhalouche, H.-Y. Huang, A. Miloudi, H. Doucet,* J.-F. Soulé* . C. R. Chim. 2019, 22, 628-638. (10.1016/j.crci.2019.10.001). Link -
A Straightforward One‐Step Access to Ticlopidine Derivatives Arylated at the C5‐Position of the Thienyl Ring via Pd‐Catalyzed Direct Arylations
D. Atoui, H. Li, R. Ben Salem, T. Roisnel, J.-F. Soulé,* H. Doucet* . Asian J. Org. Chem. 2019, 8, 2155-2161. (10.1002/ajoc.201900609). Link -
Rh(I)-Catalyzed P(III)-Directed C–H Bond Alkylation: Design of Multifunctional Phosphines for Carboxylation of Aryl Bromides with Carbon Dioxide
Z. Zhang, T. Roisnel, P. H. Dixneuf, J.-F. Soulé*. Angew. Chem. Int. Ed. 2019, 58, 14110-14114. (10.1002/anie.201906913). Link -
Regioselective Pd-Catalyzed Direct C1- and C2-Arylations of Lilolidine for the Access to 5,6-Dihydropyrrolo[3,2,1-ij]quinoline Derivatives
H.-Y. Huang, H. Li, T. Roisnel, J.-F. Soulé,* H. Doucet,* Beilstein . J. Org. Chem. 2019, 15, 2069-2075. (10.3762/bjoc.15.204). Link -
Late-Stage Diversification of Imidazole-Based Pharmaceuticals through Pd-Catalyzed Regioselective C–H Bond Arylations
A. Benzai, X. Shi, F. Derridj, T. Roisnel, H. Doucet,* J.-F. Soulé*. J. Org. Chem. 2019, 84, 13135-13143. (10.1021/acs.joc.9b01469). Link -
Reaction Conditions for the Regiodivergent Direct Arylations at C2- or C5-Positions of Oxazoles using Phosphine-Free Palladium Catalysts
X. Shi, J.-F. Soulé,* H. Doucet* . Adv. Synth. Catal. 2019, 361, 4748-4760. (10.1002/adsc.201900641). Link -
Application of Palladium-Catalyzed C(sp2)–H Bond Arylation to the Synthesis of Polycyclic (Hetero)Aromatics
W. Hagui, H. Doucet, J.-F. Soulé* . Chem. 2019, 5, 2006-2078. (10.1016/j.chempr.2019.06.005) Review. Link -
Late Stage Pd-Catalyzed C-H Bond Functionalization: A Powerful Tool for the One Step Access to Arylated Cyproheptadine and Cyclobenzaprine Derivatives
D. Atoui, H. Li, R. Ben Salem,* T. Roisnel, E. Caytan, J.-F. Soulé,* H. Doucet* . Catal. Commun 2019, 129, 105716. (10.1016/j.catcom.2019.105716). Link -
Intermolecular Followed by Intramolecular Palladium-Catalyzed Direct Arylation for the Synthesis of π-Extended Aromatic Compounds Containing One or Two Heteroelements
B. Bouzayani, R. Ben Salem,* J.-F. Soulé,* H. Doucet* . Eur. J. Org. Chem. 2019, 4581-4588. (10.1002/ejoc.201900775). Link -
Palladium-Catalyzed Successive C–H Bond Arylations and Annulations toward the π-Extension of Selenophene-Containing Aromatic Skeletons
X. Shi, S. Mao, T. Roisnel, H. Doucet*, J.-F. Soulé*. Org. Chem. Front. 2019, 6, 2398-2403. (10.1039/C9QO00218A). Link -
Reactivity of 3-Bromofuran in Pd-Catalyzed C–H Bond Arylation toward the Synthesis of 2,3,5-Triarylfurans
A. Sasmal, T. Roisnel, J. K. Bera, H. Doucet*, J.-F. Soulé*. Synthesis 2019, 51, 3241-3249. (10.1055/s-0037-1611819). Link -
Pd/C as heterogeneous catalyst for the direct arylation of (poly)fluorobenzenes
S. Mao, X. Shi, J.-F. Soulé*, H. Doucet*. Chem. Eur. J. 2019, 25, 9504-9513. (10.1002/chem.201900921). Link -
Iron-Catalyzed Carbonylative Alkyl-Acylation of Heteroarenes
Z. Yin, Z. Zhang, J.-F. Soulé, P. H. Dixneuf, X.-F. Wu*, J.. Catal. 2019, 372, 272-276. (10.1016/j.jcat.2019.03.001). Link -
Catalyst-Controlled Regiodivergent C–H Arylation Site of Fluorinated 2-Arylpyridine Derivatives: Application to Luminescent Iridium(III) Complexes
R. Boyaala, R. Touzani, T. Roisnel, V. Dorcet, E. Caytan, D. Jacquemin,* J. Boixel, V. Guerchais,* H. Doucet,* J.-F. Soulé*. ACS Catal. 2019, 9, 1320-1328. (10.1021/acscatal.8b04553). Link -
Reactivity of 4-Phenylthiazoles in Ruthenium Catalyzed Direct Arylations
A. Daher, D. Jacquemin, V. Guerchais,* J.-F. Soulé,* H. Doucet* . Appl. Organomet. Chem. 2019, 33, e4794. (10.1002/aoc.4794). Link -
Novel Cyclometallated 5-π-Delocalized Donor-1,3-Di(2-pyridyl)benzene Platinum(II) Complexes with Good Second-Order Nonlinear Optical Properties
M. Fontani, E. Garoni, A. Colombo, C. Dragonetti, S. Fantacci, H. Doucet, J.-F. Soulé, J. Boixel,* V. Guerchais,* D. Roberto*. Dalton Trans. 2019, 48, 202-208. (10.1039/C8DT03622E). Link -
Convenient Access to C10- and C11-(Di)arylated Dibenzo[b,f]azepines via Palladium-Catalyzed C-H Bonds Cleavages
H. Li, T. Roisnel, J.-F. Soulé,* H. Doucet* . Adv. Synth. Catal. 2019, 361, 791-802. (10.1002/adsc.201801203). Link -
Access to 3-(2-Oxoalkyl)-azaspiro[4.5]trienones via Acid-Triggered Oxidative Cascade Reactions through Alkenyl Peroxide Radical Intermediate
C.-S. Wang, T. Roisnel, P. H. Dixneuf, J.-F. Soulé* . Adv. Synth. Catal. 2019, 361, 445-450. (10.1002/adsc.201801203). Link -
Environmentally Benign Arylations of 5-Membered Ring Heteroarenes by Pd-Catalyzed C-H Bonds Activations
S. Mao, H. Li, X. Shi, J.-F. Soulé,* H. Doucet* . ChemCatChem 2019, 11, 269-286 (10.1002/cctc.201801448) Review. Link
2018
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Quinoxaline as Integrated Directing Group in Palladium-Catalyzed Ortho C–H Bond Arylation of the Aryl Unit of 2-Arylquinoxalines
I. Idris, F. Derridj, T. Roisnel, H. Doucet,* J.-F. Soulé*. New J. Chem. 2018, 42, 16036-16039. (10.1039/C8NJ02713G). Link -
Photoredox Catalysis for Building C–C Bonds from C(sp2)–H Bonds
C.-S. Wang, P. H. Dixneuf, J.-F. Soulé* . Chem. Rev. 2018, 118, 7532-7585 (10.1021/acs.chemrev.8b00077) Review. Link -
Reactivity of 5-aminopyrazoles bearing a cyclopropyl group at C3-position in palladium-catalyzed direct C4-arylation
A. Sidhom, J.-F. Soulé,* H. Doucet,* F. Allouche. Catal. Commun. 2018, 115, 55-58. (10.1016/j.catcom.2018.07.008). Link -
Synthesis of (Poly)halo-substituted Diarylsulfones through Palladium Catalyzed C-H Bond Sulfonylation using (Poly) Halobenzenesulfonyl Chlorides
A. Sasmal, J. K. Bera, H. Doucet,* J.-F. Soulé* . Eur. J. Org. Chem. 2018, 6114-6120. (doi:10.1002/ejoc.201800819). Link -
Exploring Green Solvents Associated to Pd/C as Heterogeneous Catalyst for Direct Arylation of Heteroaromatics with Aryl Bromides
S. Mao, X. Shi, J.-F. Soulé, H. Doucet. Adv. Synth. Catal. 2018, 360, 3306-3317. (10.1002/adsc.201800596) Selected as VIP. Link -
Metal-Free C(sp3)-H Bond Sulfonyloxylation of 2-Alkylpyridines and Alkylnitrones
C. Wang, P. H. Dixneuf, J.-F. Soulé*. Org. Biomol. Chem. 2018, 16, 4954-4957. (10.1039/C8OB01075G). Link -
Synthesis of C9,C10‐diheteroarylated phenanthrenes via palladium‐catalyzed C‐H bond activations
B. Bouzayani, R. Ben Salem,* J.-F. Soulé,* H. Doucet*. Eur. J. Org. Chem. 2018, 6092-6100. (doi:10.1002/ejoc.201800533). Link -
Late Stage Modifications of P-Containing Ligands using Transition-Metal-Catalysed C-H Bond Functionalisation
Z. Zhang, p. H. Dixneuf,* J.-F. Soulé* . Chem. Commun. 2018, 54, 7265-7280. (10.1039/C8CC02821D) Review, Selected as Front Cover. Link -
Halo-substituted benzenesulfonyls and benzenesulfinates: Convenient sources of arenes in metal-catalyzed C-C bond formation reactions for the straightforward access to halo-substituted arenes
H. Li, A. Sasmal, X. Shi, J.-F. Soulé,* H. Doucet* . Org. Biomol. Chem. 2018, 16, 4399-4423. (10.1039/C1038OB00632F). Review. Link -
Rhenium and Manganese Complexes Bearing Amino-Bis(phosphinite) Ligands: Synthesis, Characterization, and Catalytic Activity in Hydrogenation of Ketones
H. Li, D. Wei, A. Bruneau-Voisine, M. Ducamp, M. Henrion, T. Roisnel, V. Dorcet, C. Darcel, J.-F. Carpentier, J.-F. Soulé, J.-B. Sortais*. Organometallics 2018, 37, 1271-1279. (10.1021/acs.organomet.8b00020). Link -
Reactivity of 1,2,3- and 1,2,4-Trifluorobenzenes in Palladium-Catalyzed Direct Arylation
X. Shi, S. Mao, J.-F. Soulé,* H. Doucet* . J. Org. Chem. 2018, 83, 4015-4023. (10.1021/acs.joc.8b00412). Link -
Effective Modulation of 2,1,3-Benzothiadiazoles and 2,1,3-Benzoselenadiazoles Photoluminescence Properties by Pd-Catalyzed C-H Bond Arylations
I. Idris, T. Tannoux, F. Derridj, V. Dorcet, J. Boixel,* V. Guerchais, H. Doucet, J.-F. Soulé* . J. Mater. Chem. 2018, 6, 1731-1737. (10.1039/C7TC05395A). Link -
Metal-Catalyzed C−H Bond Activation of 5-Membered Carbocyclic Rings: A Powerful Access to Azulene, Acenaphthylene and Fulvene Derivatives
X. Shi, A. Sasmal, J.-F. Soulé,* H. Doucet*. Chem. Asian J. 2018, 13, 143-157 (10.1002/asia.201701455). Review Selected as Front Cover. Link -
Synthesis of mono- and di-arylated acenaphthylenes and programmed access to dibenzo[j,l]fluoranthenes via palladium-catalysed C–H bond functionalisation
X. Shi, T. Roisnel, J.-F. Soulé,* H. Doucet* . Org. Chem. Front. 2018, 5, 398-408. (10.1039/C7QO00799J). Link
2017
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Reactivity of bromoselenophenes in palladium-catalyzed direct arylations
A. Skhiri, R. Ben Salem, J.-F. Soulé,* H. Doucet,* Beilstein J.. Org. Chem. 2017, 13, 2862-2868.(10.3762/bjoc.13.278). Link -
Synthesis of 2-Pyridinemethyl Ester Derivatives from Aldehydes and 2-Alkylheterocycle N-Oxides via Copper-Catalyzed Tandem Oxidative Coupling–Rearrangement
C.-S. Wang, X.-F. Wu, P. H. Dixneuf, J.-F. Soulé* . Org. Lett. 2017, 19, 6720-6723. (10.1021/acs.orglett.7b03446). Link -
Copper-Catalyzed Oxidative Dehydrogenative C(sp3)-H Bond Amination of (Cyclo)Alkanes using NH-Free Heterocycles as Amine Sources
C.-S. Wang, X.-F. Wu, P. H. Dixneuf, J.-F. Soulé* . ChemSusChem 2017, 10, 3075-3082. (10.1002/cssc.201700783) Selected as VIP. Link -
Ruthenium-Catalyzed C-H Bond Alkylation of Arylphosphine Oxides with Alkenes: A Straightforward Access to Bifunctional Phosphorous Ligands with a Pendent Carboxylate
C.-S. Wang, P. H. Dixneuf, J.-F. Soulé* . ChemCatChem 2017, 9, 3117-3120. (DOI:10.1002/adsc.201700435). Link -
Palladium-catalyzed regioselective C–H bond arylations at the C3 position of ortho-substituted fluorobenzenes
A. Hfaiedh, H. Ben Ammar, J.-F. Soulé,* H. Doucet* . Org. Biomol. Chem. 2017, 15, 7447-7455. (DOI:10.1039/c7ob01689a). Link -
Synthesis of 2-(fluorinated aryl)pyridine derivatives via palladium-catalyzed C–H bond arylation of fluorobenzenes using 2-halopyridines as aryl sources
Boyaala, R. Touzani, V. Guerchais, J.-F. Soulé,* H. Doucet* . Tetrahedron Lett. 2017, 58, 3205-3208.(DOI:10.1016/j.tetlet.2017.06.075). Link -
Access to (Hetero)arylated Selenophenes via Palladium-catalysed Stille, Negishi or Suzuki Couplings or C−H Bond Functionalization Reaction
A. Skhiri, R. Ben Salem, J.-F. Soulé,* H. Doucet* . ChemCatChem 2017, 9, 2895-2913. (DOI:10.1002/cctc.201700256) Review. Link -
Palladium-Catalyzed Regioselective Direct Arylation of Benzofurazans at the C-4 Position
I. Idris, F. Derridj, J.-F. Soulé,* H. Doucet* . Adv. Synth. Catal. 2017, 359, 2448-2456 (DOI:10.1002/adsc.201700435). Link -
Reactivity of benzofuran and benzothiophene in palladium-catalysed direct C2,C3-diarylations
K. Si Larbi, S. Djebbar, J.-F. Soulé,* H. Doucet* . J. Organomet. Chem. 2017, 843, 32-39. (DOI:10.1021/acs.joc.6b03023). Link -
Synthesis of Phenanthrothiazoles and 1,2-Di(heteroaryl)benzenes through Successive Pd-Catalyzed Direct Arylations
X. Shi, J.-F. Soulé,* H. Doucet,* J.. Org. Chem. 2017, 82, 3886-3894. (DOI:10.1021/acs.joc.6b03023). Link -
Palladium-Catalyzed C–H Bond Functionalization of 6,6-Diphenylfulvenes: An Easier Access to C1-Arylated and C1,C4-Diarylated Fulvenes
M. Brahim, H. Ben Ammar, V. Dorcet, J.-F. Soulé,* H. Doucet* . Org. Lett. 2017, 19, 2584-2587. (DOI: 10.1021/acs.orglett.7b00900). Link -
Unprecedented access to β-arylated selenophenes via palladium-catalysed direct arylation
A. Skhiri, R. Ben Salem,* J.-F. Soulé,* H. Doucet* . Chem. Eur. J. 2017, 23, 2788-2791. (DOI:10.1002/chem.201700202). Link -
Reactivity of N-protected 5-(2-bromophenyl)tetrazoles in palladium-catalyzed direct arylation of heteroarenes or fluorobenzenes
S. Chikhi, S. Djebbar, J.-F. Soulé,* H. Doucet* . J. Organomet.Chem. 2017, 831, 55-63. (DOI:10.1016/j.jorganchem.2016.12.026). Link -
Palladium-catalysed direct arylation of heteroarenes using 1-(bromophenyl)-1,2,3-triazoles as aryl source
H. H. Mokhtar, N. Laidaoui, D. El Abed, J.-F. Soulé,* H. Doucet* . Catal. Commun. 2017, 92, 124-127. (DOI:10.1016/j.catcom.2016.12.030). Link -
Direct C3-arylation of 2H-indazole derivatives with aryl bromides using a low loading of a phosphine-free palladium-catalyst
F. Belkessam, Y M. Aidene, J.-F. Soulé,* H. Doucet* . ChemCatChem 2017, 9, 2239-2249. (DOI:10.1002/cctc.201601420). Link -
An unexpected copper-catalyzed carbonylative acetylation of amines
Y. Li, C. Wang, F. Zhu, Z. Wang, J.-F. Soulé, P. H. Dixneuf, X.-F. Wu* . Chem. Commun. 2017, 53, 142-144. (DOI:10.1039/C6CC08929A). Link
2016
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Palladium-Catalyzed Cascade sp2 C–H Bond Functionalizations Allowing One-Pot Access to 4-Aryl-1,2,3,4-tetrahydroquinolines from N-Allyl-N-arylsulfonamides
K. Yuan, J.-F. Soulé,* V. Dorcet, H. Doucet*. ACS Catal. 2016, 8121-8126. (DOI:10.1021/acscatal.6b02586). Link -
Palladium-Catalysed Desulfitative Heck Reaction Tolerant to Aryl Carbon–Halogen Bonds for Access to (Poly)halo-Substituted Stilbene or Cinnamate Derivatives
A. Skhiri, R. B. Salem,* J.-F. Soulé, H. Doucet* . Synthesis 2016, 48, 3097-3106. (DOI:10.1055/s-0035-1560449). Link -
Reactivity of (poly)fluorobenzamides in palladium-catalysed direct arylations
N. Laidaoui, M. He, D. El Abed, J.-F. Soulé,* H. Doucet* . RSC Adv. 2016, 6, 62866-62875. (DOI:10.1039/C6RA12165A). Link -
Palladium-catalyzed direct desulfitative C2 arylations of 3-halo-N-protected indoles using (hetero)arenesulfonyl chlorides
A. Hfaiedh, H. Ben Ammar, J.-F. Soulé,* H. Doucet* . Org. Biomol. Chem. 2016, 14, 4947-4956. (DOI:10.1039/C6OB00584E). Link -
Direct access to 2-(hetero)arylated pyridines from 6-substituted 2-bromopyridines via phosphine-free palladium-catalyzed C-H bond arylations: the importance of the C6 substituent
W. Hagui, N. Besbes, E. Srasra, J.-F. Soulé,* H. Doucet* . RSC Adv. 2016, 6, 17110-17117. (DOI:10.1039/C6RA01861K). Link -
Short Synthesis of Sulfur Analogues of Polyaromatic Hydrocarbons through Three Palladium-Catalyzed C–H Bond Arylations
W. Hagui, N. Besbes, E. Srasra, T. Roisnel, J.-F. Soulé,* H. Doucet* . Org. Lett. 2016, 18, 4182-4185. (DOI:10.1021/acs.orglett.6b01735). Link -
Asymmetrical 1,3-Bis(heteroazolyl)benzene Platinum Complexes with Tunable Second-Order Non-Linear Optical Properties
T. T. Dang, J.-F. Soulé, H. Doucet, M. A. Benmensour, A. Boucekkine, A. Colombo,* C. Dragonetti, S. Righetto, D. Jacquemin, J. Boixel,* V. Guerchais. Eur. J. Inorg. Chem. 2016, 4774-4782. (DOI:10.1002/ejic.201600675). Link -
Environmentally-Safe Conditions for a Palladium-Catalyzed Direct C3-Arylation with High Turn Over Frequency of Imidazo[1,2-b] pyridazines Using Aryl Bromides and Chlorides
S. Chikhi, S. Djebbar, J.-F. Soulé,* H. Doucet* . Chem. Asian J. 2016, 11, 2443-2452. (DOI:10.1002/asia.201600827). Link -
Regiocontroled Pd-catalysed C5-arylation of 3-substituted thiophene derivatives using a bromo-substituent as blocking group
M. Brahim, H. Ben Ammar, J.-F. Soulé,* H. Doucet,* Beilstein. J. Org. Chem. 2016, 12, 2197-2203. (DOI:10.3762/bjoc.12.210). Link -
Reactivity of 1-(2-bromobenzyl)-4-halopyrazoles in intermolecular and intramolecular Pd-catalysed direct arylations
M. Brahim, H. Ben Ammar, J.-F. Soulé,* H. Doucet* . Tetrahedron 2016, 72, 4312-4320. (DOI:10.1016/j.tet.2016.05.079). Link -
Regioselectivity in palladium-catalysed direct arylation of 5-membered ring heteroaromatics
C. B. Bheeter, L. Chen, J.-F. Soulé,* H. Doucet* . Catal. Sci. Technol. 2016, 6, 2005-2049. (DOI:10.1039/C5CY02095F) Review. Link -
Reactivity of 2,1-Benzisoxazole in Palladium-Catalyzed Direct Arylation with Aryl Bromides
M. Aidene, F. Belkessam, J.-F. Soulé,* H. Doucet. ChemCatChem 2016, 8, 1583-1590. (DOI:10.1002/cctc.201600047). Link -
Palladium-Catalyzed Regioselective C–H Bond Arylations of Benzoxazoles and Benzothiazoles at the C7 Position
F. Abdellaoui, C. Youssef, H. Ben Ammar, T. Roisnel, J.-F. Soulé,* H. Doucet* . ACS Catal. 2016, 6, 4248-4252. (DOI:10.1021/acscatal.6b00678) Selected as Front Cover. Link
2015
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Functionalization of C–H Bonds via Metal-Catalyzed Desulfitative Coupling: An Alternative Tool for Access to Aryl- or Alkyl-Substituted (Hetero)arenes
K. Yuan, J.-F. Soulé,* H. Doucet* . ACS Catal. 2015, 5, 978-991. (DOI:10.1021/cs501686d) Review. Link -
Desulfitative Pd-catalysed coupling reaction using benzenesulfonyl chlorides and enones as the coupling partners
K. Yuan, R. Sang, J.-F. Soulé, H. Doucet* . Catal. Sci. Technol. 2015, 5, 2904-2912. (DOI:10.1039/C5CY00089K). Link -
Intermolecular versus Intramolecular Palladium-Catalyzed Direct Arylations between 1-(2-Bromobenzyl) imidazoles and Aryl Bromides
X. Xu, L. Zhao, Y. Li,* J.-F. Soulé, H. Doucet* . Adv. Synth. Catal. 2015, 357, 2869-2882. (DOI:10.1002/adsc.201500332). Link -
Palladium-Catalysed Direct Arylation using Free-Amine-Substituted Polyfluoroanilines with Inhibition of Amination-Type Reaction
A. Takfaoui, R. Touzani,* J.-F. Soulé, P. H. Dixneuf, H. Doucet* . Asian J. Org. Chem. 2015, 4, 1085-1095. (DOI:10.1002/ajoc.201500268). Link -
Reactivity of 3-(pyrrol-1-yl)thiophenes in Pd-catalysed direct arylations
I. Smari, C. Youssef, H. Ben Ammar,* B. Ben Hassine, J.-F. Soulé, H. Doucet* . Tetrahedron 2015, 71, 6586-6593. (DOI:10.1016/j.tet.2015.03.022). Link -
Conditions for the Palladium-Catalysed Direct 2-Arylation of 3-Bromobenzo[b]thiophene Tolerant of the Benzothienyl Carbon–Bromine Bond
I. Smari, H. B. Ammar,* B. B. Hassine, J.-F. Soulé, H. Doucet* . Synthesis 2015, 47, 3354-3362. (DOI:10.1055/s-0034-1378733). Link -
Pd-Catalysed Direct Arylation of Heteroaromatics Using (Poly)halobenzenesulfonyl Chlorides as Coupling Partners: One Step Access to (Poly)halo-Substituted Bi(hetero)aryls
A. Skhiri, A. Beladhria, K. Yuan, J.-F. Soulé, R. Ben Salem,* H. Doucet* . Eur. J. Org. Chem. 2015, 4428-4436. (DOI:10.1002/ejoc.201500354). Link -
Synthesis of heteroarenes dyads from heteroarenes and heteroarylsulfonyl chlorides via Pd-catalyzed desulfitative C-H bond heteroarylations
B. Saoudi, A. Debache, J.-F. Soulé, H. Doucet,*. RSC Adv. 2015, 5, 65175-65183. (DOI:10.1039/C5RA07762A). Link -
Cyclisation reaction between 3-methylquinoxaline-2-thione and benzaldehydes into 3-benzyl-2-aryl-thieno[2,3-b]quinoxaline promoted by Brønsted acids
B. Saoudi, A. Teniou, A. Debache, T. Roisnel, J.-F. Soulé,* H. Doucet* . C. R. Chim. 2015, 18, 808-815. (DOI:10.1016/j.crci.2015.06.003). Link -
Size of Gold Nanoparticles Driving Selective Amide Synthesis through Aerobic Condensation of Aldehydes and Amines
H. Miyamura, H. Min, J.-F. Soulé, S. Kobayashi* . Angew. Chem. Int. Ed. 2015, 54, 7564-7567. (DOI:10.1002/anie.201501795). Link -
Synthesis of symmetrical and unsymmetrical 1,3-diheteroarylbenzenes through palladium-catalyzed direct arylation of benzene-1,3-disulfonyl dichloride and 3-bromobenzenesulfonyl chlorides
I. Idris, F. Derridj, S. Djebbar, J.-F. Soulé,* H. Doucet* . Tetrahedron 2015, 71, 9617-9625. (DOI:10.1016/j.tet.2015.10.082). Link -
Eco-Friendly Solvents for Palladium-Catalyzed Desulfitative C–H Bond Arylation of Heteroarenes
A. Hfaiedh, K. Yuan, H. Ben Ammar, B. Ben Hassine, J.-F. Soulé, H. Doucet* . ChemSusChem 2015, 8, 1794-1804. (DOI:10.1002/cssc.201403429). Link -
Reactivity of Para-Substituted Fluorobenzenes in Palladium-catalyzed Intermolecular Direct Arylations
M. He, J.-F. Soulé,* H. Doucet* . ChemCatChem 2015, 7, 2130-2140. (DOI:10.1002/cctc.201500185). Link -
Palladium-Catalyzed Iterative C-H Bond Arylations: Synthesis of Medium-Size Heterocycles with a Bridgehead Nitrogen Atom
W. Hagui, K. Yuan, N. Besbes, E. Srasra, J.-F. Soulé,* H. Doucet* . ChemCatChem 2015, 7, 3544-3554. (DOI:10.1002/cctc.201500652). Link -
Efficient Domino Hydroformylation/Benzoin Condensation: Highly Selective Synthesis of α-Hydroxy Ketones
K. Dong, R. Sang, J.-F. Soulé, C. Bruneau, R. Franke, R. Jackstell, M. Beller* . Chem. Eur. J. 2015, 21, 18033-18037. (DOI:10.1002/chem.201502982). Link -
Conditions for palladium-catalyzed direct arylations of 4-bromo and 4-iodo N-substituted pyrazoles without C-Br or C-I bond cleavage
M. Brahim, I. Smari, H. Ben Ammar,* B. Ben Hassine, J.-F. Soulé, H. Doucet* . Org. Chem. Front. 2015, 2, 917-926. (DOI:10.1039/C5QO00093A). Link -
Efficient synthesis of π-conjugated molecules incorporating fluorinated phenylene units through palladium-catalyzed iterative C(sp2)–H bond arylations
F. Abdelmalek, F. Derridj, S. Djebbar, J.-F. Soulé,* H. Doucet,* Beilstein J.. Org. Chem. 2015, 11, 2012-2020. (DOI:10.3762/bjoc.11.218). Link -
Palladium-catalyzed non-directed C–H bond arylation of difluorobenzenes and dichlorobenzenes bearing benzoxazole or benzothiazole
F. Abdellaoui, H. B. Ammar, J.-F. Soulé,* H. Doucet* . Catal. Commun. 2015, 71, 13-16. (DOI:10.1016/j.catcom.2015.07.025). Link
2014
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Reactivity of 3-Substituted Fluorobenzenes in Palladium- Catalysed Direct Arylations with Aryl Bromides
T. Yan, L. Zhao, M. He, J.-F. Soulé, C. Bruneau, H. Doucet,* . Adv. Synth. Catal. 2014, 356, 1586-1596. (DOI:10.1002/adsc.201400038). Link -
One pot Pd(OAc)2-catalysed 2,5-diarylation of imidazoles derivatives
A. Takfaoui, L. Zhao, R. Touzani,* J.-F. Soulé, P. H. Dixneuf, H. Doucet* . Tetrahedron 2014, 70, 8316-8323. (DOI:10.1016/j.tet.2014.09.012). Link -
Palladium-Catalysed Direct Desulfitative Arylation of Pyrroles using Benzenesulfonyl Chlorides as Alternative Coupling Partners
R. Jin, K. Yuan, E. Chatelain, J.-F. Soulé,* H. Doucet* . Adv. Synth. Catal. 2014, 356, 3831-3841. (DOI:10.1002/adsc.201400736). Link -
Synthesis of (Poly)fluorobiphenyls through Metal-catalyzed C-H Bond Activation/Arylation of (Poly)fluorobenzene Derivatives
M. He, J.-F. Soulé,* H. Doucet* . ChemCatChem 2014, 6, 1824-1859. (DOI:10.1002/cctc.201402020) Review. Link -
Palladium-catalyzed 2,5-diheteroarylation of 2,5-dibromothiophene derivatives
F. Belkessam, A. Mohand, J.-F. Soulé, A. Elias,* H. Doucet,* Beilstein. J. Org. Chem. 2014, 10, 2912-2919. (DOI:10.3762/bjoc.10.309). Link -
Benzenesulfonyl Chlorides: Alternative Coupling Partners for Regiocontrolled Palladium-Catalyzed Direct Desulfitative 5-Arylation of Furans
A. Beladhria, K. Yuan, H. Ben Ammar, J.-F. Soulé, R. Ben Salem, H. Doucet* . Synthesis 2014, 46, 2515-2523. (DOI:10.1055/s-0033-1340188). Link -
A Simple and Efficient Synthesis of (Hetero)Aryl-Substituted Benzothiazolyl or Benzoxazolyl Furan, Thiophene and N-methylpyrrole Derivatives through a Palladium-Catalyzed Regioselective C–H Bond Arylation
F. Abdellaoui, C. Youssef, H. Ben Ammar, J.-F. Soulé, H. Doucet* . Synthesis 2014, 46, 3341-3350. (DOI:10.1055/s-0034-1379021). Link -
Direct Amidation from Alcohols and Amines through a Tandem Oxidation Process Catalyzed by Heterogeneous-Polymer-Incarcerated Gold Nanoparticles under Aerobic Conditions
J.-F. Soulé, H. Miyamura, S. Kobayashi* . Chem. Asian J. 2013, 8, 2614-2626. (DOI:10.1002/asia.201300733). Link
2013
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Copolymer-Incarcerated Nickel Nanoparticles with N-Heterocyclic Carbene Precursors as Active Cross-Linking Agents for Corriu–Kumada–Tamao Reaction
J.-F. Soulé, H. Miyamura, S. Kobayashi* . J. Am. Chem. Soc. 2013, 135, 10602-10605. (DOI:10.1021/ja404006w). Link -
Selective imine formation from alcohols and amines catalyzed by polymer incarcerated gold/palladium alloy nanoparticles with molecular oxygen as an oxidant
J.-F. Soulé, H. Miyamura, S. Kobayashi* . Chem. Commun. 2013, 49, 355-357. (DOI:10.1039/C2CC36213A). Link
2012
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Conformational Study of Glycal-Type Neuraminidase Inhibitors
G. Surpateanu, J.-F. Soulé, J.-M. Beau,* S. Norsikian, B. I. Iorga,* J.. Carbohydr. Chem. 2012, 31, 114-129. (DOI:10.1080/07328303.2011.636161). Link -
Selective Lactam Formation from Amino Alcohols Using Polymer-Incarcerated Gold and Gold/Cobalt Nanoparticles as Catalysts under Aerobic Oxidative Conditions
J.-F. Soulé, H. Miyamura, S. Kobayashi* . Asian J. Org. Chem. 2012, 1, 319-321. (DOI:10.1002/ajoc.201200093). Link -
Remarkable Stereoselectivity in Intramolecular Borono-Mannich Reactions: Synthesis of Conduramines
S. Norsikian,* J.-F. Soulé, A. Cannillo, R. Guillot, M.-E. Tran Huu Dau, J.-M. Beau* . Org. Lett. 2012, 14, 544-547. (DOI:10.1021/ol203162s). Link
2011
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Powerful Amide Synthesis from Alcohols and Amines under Aerobic Conditions Catalyzed by Gold or Gold/Iron, -Nickel or -Cobalt Nanoparticles
J.-F. Soulé, H. Miyamura, S. Kobayashi,* J.. Am. Chem. Soc. 2011, 133, 18550-18553. (DOI:10.1021/ja2080086). Link
2010
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Coupling the Petasis Condensation to an Iron(III) Chloride-Promoted Cascade Provides a Short Synthesis of Relenza Congeners
J.-F. Soulé, A. Mathieu, S. Norsikian,* J.-M. Beau* . Org. Lett. 2010, 12, 5322-5325. (DOI:10.1021/ol102326b). Link
Book Chapters
Patents


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