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Catalysis for Heterocycles Chemistry

Catalysis for Heterocycles Chemistry

Heterocycles, with their diverse structures and extensive applications in pharmaceuticals, materials, and agrochemicals, often necessitate targeted modifications at specific positions to enhance their properties. In this regard, our research group is actively engaged in the development of innovative catalytic methods for C–H bond functionalization in heterocycles. We explore various transition metals (Pd, Ru, Rh, and Ir) in conjunction with directing groups or ligands to achieve selective transformations. Additionally, we anticipate the use of cascade reactions initiated by C–H bond activation, offering efficient synthetic routes to access a wide range of diverse heterocyclic compounds.


Key References

PIFA-Mediated Cyclization of Methyl(2-(1-Phenylvinyl)Phenyl)Sulfane for the Concise, Flexible, and Scalable De Novo Synthesis of C3-Arylated Benzo[b]Thiophenes
X. Liu, O. Provot,* C. Tran,* J. F. Soulé, A. Hamze*. Org. Chem. Front. 2025, 12, 24-32. (10.1039/D4QO01589D).  Link
Rhodium-Catalyzed C–H Bond Annulation for the Synthesis of 5- and 6-Membered N-Heterocyclic Building Blocks
M. Peng, H. Doucet, J.-F. Soulé*. ChemCatChem 2024, e202400279. (10.1002/cctc.202400279).  Link
104.beta pyrazole3
C−H Bond Arylation of Pyrazoles at the β-Position: General Conditions and Computational Elucidation for a High Regioselectivity
X. Shi, E. D. Sosa Carrizo, M. Cordier, J. Roger, N. Pirio, J.-C. Hierso, P. Fleurat-Lessard,* J.-F. Soulé,* H. Doucet*. Chem. Eur. J.  2021, 27, 5546-5554 (10.1002/chem.202100031).  Link
78.radical cyclization–asc
Access to 3-(2-Oxoalkyl)-azaspiro[4.5]trienones via Acid-Triggered Oxidative Cascade Reactions through Alkenyl Peroxide Radical Intermediate
C.-S. Wang, T. Roisnel, P. H. Dixneuf, J.-F. Soulé* . Adv. Synth. Catal. 2019, 361, 445-450. (10.1002/adsc.201801203).  Link
51.toc ayman se2
Unprecedented access to β-arylated selenophenes via palladium-catalysed direct arylation
A. Skhiri, R. Ben Salem,* J.-F. Soulé,* H. Doucet* . Chem. Eur. J. 2017, 23, 2788-2791. (DOI:10.1002/chem.201700202).  Link